Hdac2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Hdac2^tm1Lex
• Name: histone deacetylase 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5613704
• Gene: Hdac2 Location: Chr10:36850540-36877885 bp, + strand Genetic Position: Chr10, 19.44 cM, cytoband B1
• Alliance: Hdac2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214041
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neomycin resistance cassette replaced exons 2 through 5. Enzymatic activity confirmed a reduction in class I HDAC activity in the retina. (J:214041)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hdac2 Mutation: 40 strains or lines available

References

• Original: J:214041 Fan J, et al., Inhibition of HDAC2 protects the retina from ischemic injury. Invest Ophthalmol Vis Sci. 2013 Jun;54(6):4072-80
• All: 1 reference(s)