Kcnip2^tm1Jmn
Targeted Allele Detail

Summary

• Symbol: Kcnip2^tm1Jmn
• Name: Kv channel-interacting protein 2; targeted mutation 1, Jeanne Nerbonne
• MGI ID: MGI:5613711
• Gene: Kcnip2 Location: Chr19:45780785-45804948 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband D1
• Alliance: Kcnip2^tm1Jmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214199
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 4 through 9, eliminating the majority of the C-terminal core domain. Western blot analysis confirmed the absence of protein expression in the brain. (J:214199)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnip2 Mutation: 28 strains or lines available

References

• Original: J:214199 Foeger NC, et al., Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents. J Physiol. 2013 Sep 1;591(Pt 17):4149-66
• All: 1 reference(s)