Tshb^tm1Hru
Targeted Allele Detail

Summary

• Symbol: Tshb^tm1Hru
• Name: thyroid stimulating hormone, beta subunit; targeted mutation 1, Hiroki R Ueda
• MGI ID: MGI:5613811
• Synonyms: TSHbeta^Luc
• Gene: Tshb Location: Chr3:102682781-102690034 bp, - strand Genetic Position: Chr3, 45.25 cM
• Alliance: Tshb^tm1Hru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214030
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A firefly luciferase cassette and floxed neomycin resistance cassette replaced the coding sequence in exon 4. QRT-PCR confirmed the absence of transcript expression in the pituitary. (J:214030)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tshb Mutation: 14 strains or lines available

References

• Original: J:214030 Tsujino K, et al., Establishment of TSH beta real-time monitoring system in mammalian photoperiodism. Genes Cells. 2013 Jul;18(7):575-88
• All: 1 reference(s)