Camk2a^tm1Kub
Targeted Allele Detail

Summary

• Symbol: Camk2a^tm1Kub
• Name: calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1, K Ulrich Bayer
• MGI ID: MGI:5613814
• Gene: Camk2a Location: Chr18:61058704-61121224 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Camk2a^tm1Kub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208776
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted in intron 9 via homologous recombination. Expression of Camk2b is enhanced in homozygous mice. Western blot analysis indicates loss of Camk2a expression in the neocortex and hippocampus of homozygous mice. (J:208776)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Camk2a^tm1Kub/Camk2a^tm1Kub	involves: 129 * C57BL/6

Phenotypes:

Affected Systems	hm1
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nervous system	√
absent long-term depression	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2a Mutation: 135 strains or lines available

References

• Original: J:208776 Coultrap SJ, et al., Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection. Cell Rep. 2014 Feb 13;6(3):431-7
• All: 1 reference(s)