Osbp2^tm1Arai
Targeted Allele Detail

Summary

• Symbol: Osbp2^tm1Arai
• Name: oxysterol binding protein 2; targeted mutation 1, Hiroyuki Arai
• MGI ID: MGI:5613891
• Gene: Osbp2 Location: Chr11:3653731-3813903 bp, - strand Genetic Position: Chr11, 2.6 cM
• Alliance: Osbp2^tm1Arai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215726
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 4 through 9, which encodes the FFAT motif and the anterior half of the sterol-binding domain. Western blot and immunohistochemical analysis confirmed the absence of protein expression in testis and seminiferous tubules. (J:215726)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Osbp2 Mutation: 31 strains or lines available

References

• Original: J:215726 Udagawa O, et al., Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family. Genes Cells. 2014 Jan;19(1):13-27
• All: 1 reference(s)