Mex3c^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Mex3c^tm1Aki
• Name: mex3 RNA binding family member C; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:5613894
• Gene: Mex3c Location: Chr18:73706115-73725646 bp, + strand Genetic Position: Chr18, 49.29 cM
• Alliance: Mex3c^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208870
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Exon 2 was replaced a neo cassette in the opposite orientation via homologous recombination. (J:208870)

Generation of the Mex3c^tm1Aki mice

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mex3c Mutation: 20 strains or lines available

References

• Original: J:208870 Kuniyoshi K, et al., Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51
• All: 1 reference(s)