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Cpaptm1d(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Cpaptm1d(EUCOMM)Wtsi
Name: centrosome assembly and centriole elongation protein; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:5613963
Synonyms: Sas-4-
Gene: Cpap  Location: Chr14:56764218-56812882 bp, - strand  Genetic Position: Chr14, 28.28 cM
Alliance: Cpaptm1d(EUCOMM)Wtsi page
IMPC: Cpap gene page
Mutation
origin
Mutant Cell Line:  EPD0028_7_G05
Germline Transmission:  Earliest citation of germline transmission: J:208632
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_gt1
 
Mutation detailsThe L1L2_gt1 cassette was inserted at position 56792283 of Chromosome 14 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 56793168. The critical exon(s) is/are thus flanked by loxP sites. Cre and flp mediated recombination created the knockout allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpap Mutation:  44 strains or lines available
References
Original:  J:208632 Bazzi H, et al., Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1491-500
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory