Rbl1^tm1.1Fad
Targeted Allele Detail

Summary

• Symbol: Rbl1^tm1.1Fad
• Name: RB transcriptional corepressor like 1; targeted mutation 1.1, Frederick A Dick
• MGI ID: MGI:5614063
• Synonyms: p107^deltaD, Rbl1^deltaD
• Gene: Rbl1 Location: Chr2:156987813-157046454 bp, - strand Genetic Position: Chr2, 78.05 cM
• Alliance: Rbl1^tm1.1Fad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217445
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 20 was replaced with one in which substitutions (I926A, N930A, and V934A) abolished the ability of the product to form the DREAM complex. Cre-mediated recombination removed a floxed neomycin resistance cassette inserted downstream of exon 20. (J:217445)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbl1 Mutation: 60 strains or lines available

References

• Original: J:217445 Forristal C, et al., Loss of the mammalian DREAM complex deregulates chondrocyte proliferation. Mol Cell Biol. 2014 Jun;34(12):2221-34
• All: 2 reference(s)