Aars1^tm1.1Slac
Targeted Allele Detail

Summary

• Symbol: Aars1^tm1.1Slac
• Name: alanyl-tRNA synthetase 1; targeted mutation 1.1, Susan L Ackerman
• MGI ID: MGI:5614439
• Gene: Aars1 Location: Chr8:111759781-111784237 bp, + strand Genetic Position: Chr8, 57.9 cM
• Alliance: Aars1^tm1.1Slac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216802
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Hypomorph, Inducible)
• Inducer: not specified
• Mutation: Nucleotide substitutions
• Mutation details: Cre-excision of the loxP-flanked stop-neo cassette in the tm1Slac allele results in active expression of this hypomorph with a TGT to GCG substitution that results in the substitution of Cysteine to Alanine at amino acid 723. (J:216802)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aars1 Mutation: 69 strains or lines available

References

• Original: J:216802 Liu Y, et al., Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17570-5
• All: 1 reference(s)