Ripk3^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Ripk3^tm1Arte
• Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:5614565
• Synonyms: Ripk3^LSL
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209137
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A GAT to AAT mutation was inserted in exon 4 resulting in the replacement of aspartic acid at position 161 by asparagine (D161N). A loxP-Stop-loxP (LSL) transcription termination cassette was inserted in intron 3. The LSL cassette can be removed via cre-mediated recombination which results in expression of the D161N mutant allele. (J:209137)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 34 strains or lines available

References

• Original: J:209137 Newton K, et al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
• All: 5 reference(s)