Ripk1^tm1Geno
Targeted Allele Detail

Summary

• Symbol: Ripk1^tm1Geno
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1; targeted mutation 1, Genoway
• MGI ID: MGI:5614572
• Synonyms: Ripk1^D138N
• Gene: Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
• Alliance: Ripk1^tm1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209137
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A GAC to AAC mutation was inserted in exon 4 resulting in the replacement of aspartic acid at position 138 by asparagine (D138N). (J:209137)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk1 Mutation: 33 strains or lines available

References

• Original: J:209137 Newton K, et al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
• All: 20 reference(s)