Casp8^tm1.1Vmd
Targeted Allele Detail

Summary

• Symbol: Casp8^tm1.1Vmd
• Name: caspase 8; targeted mutation 1.1, Vishva M Dixit
• MGI ID: MGI:5614580
• Gene: Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^tm1.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209137
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The loxP site flanked exon 3 was removed via Cre-mediated recombination. (J:209137)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 45 strains or lines available

References

• Original: J:209137 Newton K, et al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
• All: 14 reference(s)