Trpc4^tm1.1Clph
Targeted Allele Detail

Summary

• Symbol: Trpc4^tm1.1Clph
• Name: transient receptor potential cation channel, subfamily C, member 4; targeted mutation 1.1, David E Clapham
• MGI ID: MGI:5615468
• Gene: Trpc4 Location: Chr3:54063456-54225892 bp, + strand Genetic Position: Chr3, 25.43 cM, cytoband D
• Alliance: Trpc4^tm1.1Clph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209620
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Cre mediated recombination removed exon 4 and the neo cassette. Western blot analysis confirmed the absence of protein expression in brain microsomes from homozygous mice. (J:209620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Trpc4 Mutation: 60 strains or lines available

References

• Original: J:209620 Riccio A, et al., Decreased anxiety-like behavior and Galphaq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci. 2014 Mar 5;34(10):3653-67
• All: 5 reference(s)