Jak3^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Jak3^m1Btlr
• Name: Janus kinase 3; mutation 1, Bruce Beutler
• MGI ID: MGI:5615718
• Synonyms: mount_tai
• Gene: Jak3 Location: Chr8:72129027-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Jak3^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A-to-G transition at base pair 71,683,377 (GRCm38) on chromosome 8, or base pair 6,995 in the GenBank genomic region NC_000074. The mutation corresponds to residue 2,030 in the mRNA sequence NM_010589 within exon 14 of 25 total exons. The mutation results in a tyrosine (Y) to cysteine (C) substitution at position 607 (p.Y607C). (J:217795)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak3 Mutation: 84 strains or lines available

References

• Original: J:217795 Zeng M, et al., Mutagenetix entry for mount_tai. MGI Direct Data Submission. 2015
• All: 2 reference(s)