Irf7^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irf7^M2Btlr
• Name: interferon regulatory factor 7; mutation 2, Bruce Beutler
• MGI ID: MGI:5615723
• Synonyms: Houstonian
• Gene: Irf7 Location: Chr7:140843096-140846412 bp, - strand Genetic Position: Chr7, 86.57 cM, cytoband F5
• Alliance: Irf7^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagensis induced an A to G transition at base pair 141,264,022 (v38) on chromosome 7, or base pair 2,478 in the GenBank genomic region NC_000073. The mutation corresponds to residue 1,179 in the mRNA sequence NM_016850 within exon 8 of 10 total exons. The mutation results in a threonine (T) to alanine (A) substitution at position 246 (T246A). (J:217798)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf7 Mutation: 23 strains or lines available

References

• Original: J:217798 Dao D, et al., Mutagenetix entry for Houstonian. MGI Direct Data Submission. 2015
• All: 1 reference(s)