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Myd88tm1.1Medz
Targeted Allele Detail
Summary
Symbol: Myd88tm1.1Medz
Name: myeloid differentiation primary response gene 88; targeted mutation 1.1, Ruslan Medzhitov
MGI ID: MGI:5616077
Synonyms: Myd88FL
Gene: Myd88  Location: Chr9:119165000-119169084 bp, - strand  Genetic Position: Chr9, 71.33 cM
Alliance: Myd88tm1.1Medz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209373
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 3-5, encoding the Toll-IL-1 receptor (TIR) domain, were flanked by loxP sites. The frt-flanked neomycin resistance cassette was removed via flp-mediated recombination. When the floxed region is removed via cre-mediated recombination, splicing from exon 2 to exon 6 results in a frameshift mutation. (J:209373)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myd88 Mutation:  52 strains or lines available
References
Original:  J:209373 Schenten D, et al., Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Immunity. 2014 Jan 16;40(1):78-90
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory