Bmp10b2b2711Clo
Chemically induced Allele Detail
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Symbol: |
Bmp10b2b2711Clo |
Name: |
bone morphogenetic protein 10; Bench to Bassinet Program (B2B/CVDC), mutation 2711 Cecilia Lo |
MGI ID: |
MGI:5616117 |
Gene: |
Bmp10 Location: Chr6:87405976-87411494 bp, + strand Genetic Position: Chr6, 37.96 cM, cytoband D2
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Alliance: |
Bmp10b2b2711Clo page
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Mutant (E16.5) exhibits a hypoplastic thymus.
Show the 10 phenotype image(s) involving this allele.
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Strain of Origin: |
C57BL/6J
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Project Collection: |
B2B/CvDC
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Undefined
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Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is an A to G substitution at coding nucleotide 328 in exon 1 of the cDNA (c.328A>G, NM_009756). This changes the asparagine residue to aspartic acid at position 110 of the encoded protein (p.N110D).
(J:175213)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Bmp10 Mutation: |
23 strains or lines available
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Summative Diagnosis:
Cardiovascular phenotypes: Double outlet right ventricle (DORV) - Tetralogy of Fallot type DORV, subaortic ventricular septal defect (VSD), and hypoplastic pulmonary artery.
Noncardiovascular phenotype: Petechiae, hypoplastic thymus, curly tail, and cystic kidneys with tubule dilations.
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