Gt(ROSA)26Sor^{tm1(Irx3*)Hui}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Irx3*)Hui}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Chi-Chung Hui
• MGI ID: MGI:5616234
• Synonyms: EnR-Irx3
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Irx3*)Hui} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208887
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Irx3*)Hui} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Irx3	Expresses a dominant negative fusion gene

• Mutation details: A construct containing a floxed stop cassette and a dominant negative form of Irx3, consisting of Irx3 fused to the Engrailed repressor domain, was inserted in the locus. (J:208887)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:208887 Smemo S, et al., Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20;507(7492):371-5
• All: 2 reference(s)