Ppm1a^tm1.2Lavi
Targeted Allele Detail

Summary

• Symbol: Ppm1a^tm1.2Lavi
• Name: protein phosphatase 1A, magnesium dependent, alpha isoform; targeted mutation 1.2, Sara Lavi
• MGI ID: MGI:5616245
• Gene: Ppm1a Location: Chr12:72804231-72846593 bp, + strand Genetic Position: Chr12, 30.26 cM, cytoband C3
• Alliance: Ppm1a^tm1.2Lavi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216372
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and a frt-flanked neomycin resistance cassette was inserted upstream of exon 2. The neomycin cassette was removed via flp-mediated recombination and exon 2 was deleted via cre-mediated recombination. Western blot analysis confirmed absence of protein in protein extracts from tails. (J:216372)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppm1a Mutation: 23 strains or lines available

References

• Original: J:216372 Dvashi Z, et al., Protein Phosphatase Magnesium Dependent 1A Governs the Wound Healing-Inflammation-Angiogenesis Cross Talk on Injury. Am J Pathol. 2014;184(11):2936-50
• All: 1 reference(s)