Ntrk2^{tm3.1(cre/ERT2)Ddg}
Targeted Allele Detail

Summary

• Symbol: Ntrk2^{tm3.1(cre/ERT2)Ddg}
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 3.1, David D Ginty
• MGI ID: MGI:5616440
• Synonyms: TrkB^CreER, TrkB-CreERT2, TrkB^CreERT2
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^{tm3.1(cre/ERT2)Ddg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Ntrk2^{tm3.1(cre/ERT2)Ddg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ntrk2 (MGI:97384)

• Mutation details: A Cre recombinase-estrogen receptor T2 (CreERT2) fusion-FRT-Neomycin-FRT-loxP cassette was introduced into the first coding ATG of exon 2. All 212 bp of exon 2 (encoding the first 70 amino acids containing entire signal peptide) were replaced. (J:192549, J:218012)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ntrk2 (mouse) Summary of all recombinase alleles driven by Ntrk2. Comparative matrix view of recombinase activities Alliance mouse Ntrk2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:192549 Liu Y, et al., Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. Science. 2012 Dec 7;338(6112):1357-60
• All: 29 reference(s)