Gt(ROSA)26Sor^{tm3(CAG-Cre/ERT2)Dsa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(CAG-Cre/ERT2)Dsa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Dieter Saur
• MGI ID: MGI:5616874
• Synonyms: FSF-R26-CAG-CreER
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(CAG-Cre/ERT2)Dsa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218155
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(CAG-Cre/ERT2)Dsa} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: A targeting vector containing a CAG promoter and a FRT-flanked transcriptional and translational stop sequence with a neomycin resistance gene 5' of the CreERT2 expression cassette was generated. (J:218155)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm3(CAG-Cre/ERT2)Dsa}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:218155 Schonhuber N, et al., A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov;20(11):1340-7
• All: 21 reference(s)