Ntrk2^tm4.1Ddg
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm4.1Ddg
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 4.1, David G Ginty
• MGI ID: MGI:5617004
• Synonyms: TrkB^f
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm4.1Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192549
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 15 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:192549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:192549 Liu Y, et al., Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. Science. 2012 Dec 7;338(6112):1357-60
• All: 5 reference(s)