Cd96^tm1.1Mjs
Targeted Allele Detail

Summary

• Symbol: Cd96^tm1.1Mjs
• Name: CD96 antigen; targeted mutation 1.1, Mark J Smyth
• MGI ID: MGI:5617136
• Gene: Cd96 Location: Chr16:45856020-45940614 bp, - strand Genetic Position: Chr16, 30.45 cM, cytoband B5
• Alliance: Cd96^tm1.1Mjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209990
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exons 1 and 2, including the start site, were replaced with a loxP site flanked neomycin resistance gene cassette. Subsequent cre-mediated recombination removed the neo cassette. (J:209990)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Cd96^tm1.1Mjs/Cd96^tm1.1Mjs	B6.129P2(Cg)-Cd96^tm1.1Mjs

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
embryo	N
embryo phenotype	N
endocrine/exocrine glands	N
endocrine/exocrine gland phenotype	N
hematopoietic system	√
hematopoietic system phenotype	N
abnormal NK cell physiology	√
homeostasis/metabolism	√
decreased incidence of tumors by chemical induction	√
immune system	√
immune system phenotype	N
abnormal NK cell physiology	√
increased inflammatory response	√
increased susceptibility to endotoxin shock	√
neoplasm	√
decreased incidence of tumors by chemical induction	√
decreased metastatic potential	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd96 Mutation: 43 strains or lines available

References

• Original: J:209990 Chan CJ, et al., The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nat Immunol. 2014 May;15(5):431-8
• All: 4 reference(s)