Ifih1^Rgsc422
Chemically induced Allele Detail

Summary

• Symbol: Ifih1^Rgsc422
• Name: interferon induced with helicase C domain 1; RIKEN Genomic Sciences Center (GSC), 422
• MGI ID: MGI:5617217
• Synonyms: Ifih1^gs, MDA5^G821S
• Gene: Ifih1 Location: Chr2:62426142-62476599 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C3
• Alliance: Ifih1^Rgsc422 page

Mutation origin

• Strain of Origin: C57BL/6JJcl
• Project Collection: RIKEN GSC ENU Project

Mutation description

• Allele Type: Chemically induced (ENU) (Constitutively active)
• Mutation: Single point mutation
• A single base substitution in exon 13 results in a G821S amino acid exchange. (J:209917)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifih1 Mutation: 45 strains or lines available

References

• Original: J:209917 Funabiki M, et al., Autoimmune disorders associated with gain of function of the intracellular sensor MDA5. Immunity. 2014 Feb 20;40(2):199-212
• All: 4 reference(s)