Ipo11^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Ipo11^{tm1.1(KOMP)Vlcg}
• Name: importin 11; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5617259
• Synonyms: Ipo11^-
• Gene: Ipo11 Location: Chr13:106930947-107073466 bp, - strand Genetic Position: Chr13, 58.06 cM
• Alliance: Ipo11^{tm1.1(KOMP)Vlcg} page
• IMPC: Ipo11 gene page

Ipo11^{tm1.1(KOMP)Vlcg}/Ipo11^{tm1.1(KOMP)Vlcg} mice show embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos form a rudimentary egg-cylinder but are smaller and no primitive streak or hallmarks of gastrulation are seen at E7.5.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 14956A-A7
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 27928bp between positions 107687300-107715227 of Chromosome 13 (Genome Build37) and subsequent Cre-mediated excision deleted the neomycin resistance cassette. (J:136110, J:188991)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ipo11 Mutation: 167 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 5 reference(s)