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Col1a1tm2(tetO-IDH2*R140Q)Ppp
Targeted Allele Detail
Summary
Symbol: Col1a1tm2(tetO-IDH2*R140Q)Ppp
Name: collagen, type I, alpha 1; targeted mutation 2, Pier Paolo Pandolfi
MGI ID: MGI:5617498
Synonyms: IDH2R140Q
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm2(tetO-IDH2*R140Q)Ppp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210097
Parent Cell Line:  C2 (Jaenisch) (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Col1a1tm2(tetO-IDH2*R140Q)Ppp expresses 1 gene
 
Mutation detailsA cassette with a tetracycline response element driving expression of IDH2 with an R140Q mutation was inserted into the locus. (J:210097)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  163 strains or lines available
Notes
C2 (Jaenisch) ES cells are derived from ES cell line v6.5.
References
Original:  J:210097 Kats LM, et al., Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance. Cell Stem Cell. 2014 Mar 6;14(3):329-41
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory