Drd2^tm1.1Mmsh
Targeted Allele Detail

Summary

• Symbol: Drd2^tm1.1Mmsh
• Name: dopamine receptor D2; targeted mutation 1.1, Masayoshi Mishina
• MGI ID: MGI:5617501
• Synonyms: Drd2^flox
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm1.1Mmsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210178
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A loxP site and FRT flanked neo cassette were inserted 380 bp upstream of exon 2 and a loxP site was inserted 379 bp downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:210178)

Generation of the Drd2^tm1.1Mmsh allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:210178 Ikegami M, et al., Striatal dopamine D1 receptor is essential for contextual fear conditioning. Sci Rep. 2014;4:3976
• All: 1 reference(s)