Hist1^tm1Sis
Targeted Allele Detail

Summary

• Symbol: Hist1^tm1Sis
• Name: histone cluster 1; targeted mutation 1, Shunsuke Ishii
• MGI ID: MGI:5617502
• Synonyms: Th2a^-Th2b^-
• Gene: Hist1 Location: unknown Genetic Position: Chr13, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210169
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Hist1^tm1Sis involves 2 genes/genome features (H2bc1, H2ac1) View all
• Mutation details: A 3.7 kb region, which includes exons of both Hist1h2aa and Hist1h2ba as well as the common promoter located between the genes, was replaced with a neo cassette via homologous recombination. (J:210169)

Expression

In Mice Carrying this Mutation:

17 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hist1 Mutation: 2 strains or lines available

References

• Original: J:210169 Shinagawa T, et al., Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells. Cell Stem Cell. 2014 Feb 6;14(2):217-27
• All: 2 reference(s)