Sostdc1^tm2Snd
Targeted Allele Detail

Summary

• Symbol: Sostdc1^tm2Snd
• Name: sclerostin domain containing 1; targeted mutation 2, Scott Sunders
• MGI ID: MGI:5617945
• Synonyms: Wise^-
• Gene: Sostdc1 Location: Chr12:36364168-36368451 bp, + strand Genetic Position: Chr12, 16.82 cM, cytoband B2
• Alliance: Sostdc1^tm2Snd page

Genetic correction of Wise with Lrp5 during ossification

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216098
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A neoLacZ cassette containing stop codons at the 3' end was inserted into exon 1. For unknown reasons, the lacZ gene inserted into the locus is not expressed. (J:216098)

Generation of the Sostdc1^tm1Snd and Sostdc1^tm2Snd alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sostdc1 Mutation: 28 strains or lines available

References

• Original: J:216098 Ellies DL, et al., Wise regulates bone deposition through genetic interactions with Lrp5. PLoS One. 2014;9(5):e96257
• All: 1 reference(s)