Lamp2^tm1Amcu
Targeted Allele Detail

Summary

• Symbol: Lamp2^tm1Amcu
• Name: lysosomal-associated membrane protein 2; targeted mutation 1, Ana Maria Cuervo
• MGI ID: MGI:5617956
• Synonyms: L2A^F
• Gene: Lamp2 Location: ChrX:37490234-37545331 bp, - strand Genetic Position: ChrX, 22.67 cM
• Alliance: Lamp2^tm1Amcu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215605
• Parent Cell Line: PTL1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP sequence was inserted upstream of the 508bp region in exon 8A that encodes for the LAMP2 variant followed by a Frt-Neo-Frt-LoxP cassette. (J:215605)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lamp2^tm1Amcu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamp2 Mutation: 15 strains or lines available

Notes

60885-61392 bp of the lamp2 gene

References

• Original: J:215605 Schneider JL, et al., Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab. 2014 Sep 2;20(3):417-32
• All: 11 reference(s)