Ndrg2^tm1Kmori
Targeted Allele Detail

Summary

• Symbol: Ndrg2^tm1Kmori
• Name: N-myc downstream regulated gene 2; targeted mutation 1, Kazuhiro Morishita
• MGI ID: MGI:5617965
• Synonyms: NDRG2^-
• Gene: Ndrg2 Location: Chr14:52142738-52151463 bp, - strand Genetic Position: Chr14, 26.72 cM
• Alliance: Ndrg2^tm1Kmori page

Ndrg2^tm1Kmori/Ndrg2⁺ mice are susceptible to tumour formation

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210264
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A lacZ-pA-neo-pA cassette was inserted into exon 2. Western blot analysis confirmed the absence of protein expression in the brains from homozygous mice. (J:210264)

Generation of Ndrg2^tm1Kmori allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndrg2 Mutation: 27 strains or lines available

References

• Original: J:210264 Nakahata S, et al., Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393
• All: 2 reference(s)