Tg(Prox1-cre/ERT2)1Tmak
Transgene Detail

Summary

• Symbol: Tg(Prox1-cre/ERT2)1Tmak
• Name: transgene insertion 1, Taija Makinen
• MGI ID: MGI:5617984
• Synonyms: Prox1-CreER^T2, Tg(Prox1-cre/ERT2)#aTmak
• Transgene: Tg(Prox1-cre/ERT2)1Tmak Location: unknown
• Alliance: Tg(Prox1-cre/ERT2)1Tmak page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Prox1-cre/ERT2)1Tmak expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prox1 (MGI:97772)

• Mutation details: The BAC clone RP23-190F21 is used to generate a transgene in which a cre/ERT2 fusion was inserted at the Prox1 start codon. Two founders were generated and the one (line 1) with complete recombination in all Prox1-expressing tissues was used for further studies. (J:218590)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prox1 (mouse) Summary of all recombinase alleles driven by Prox1. Comparative matrix view of recombinase activities Alliance mouse Prox1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:218590 Bazigou E, et al., Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice. J Clin Invest. 2011 Aug;121(8):2984-92
• All: 68 reference(s)