Ly6k^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Ly6k^tm1Osb
• Name: lymphocyte antigen 6 family member K; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:5618096
• Gene: Ly6k Location: Chr15:74668723-74671817 bp, - strand Genetic Position: Chr15, 34.28 cM, cytoband E1
• Alliance: Ly6k^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210341
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2, 3, and 4 were replaced with neomycin cassette in reverse orientation relative to Ly6k gene. Western analysis confirmed the absent of LY6K protein expression. (J:210341)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ly6k Mutation: 9 strains or lines available

Notes

EGR-G01 cells carry one copy of Tg(CAG-EGFP,Acr-EGFP)2Osb. J:210341 does not specify whether the transgene is present in the line of mice created.

References

• Original: J:210341 Fujihara Y, et al., GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Biol Reprod. 2014 Mar;90(3):60
• All: 3 reference(s)