Irf8^tm2.1Hm
Targeted Allele Detail

Summary

• Symbol: Irf8^tm2.1Hm
• Name: interferon regulatory factor 8; targeted mutation 2.1, Herbert Morse III
• MGI ID: MGI:5618103
• Synonyms: IRF8-EGFP
• Gene: Irf8 Location: Chr8:121463097-121483433 bp, + strand Genetic Position: Chr8, 70.05 cM
• Alliance: Irf8^tm2.1Hm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218664
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to replace the stop codon of the endogenous gene with an enhanced green fluorescent protein (EFGP) sequence and polyadenylation sequence, followed by a loxP-flanked neomycin resistance (neo) cassette. Cre-mediated recombination removed the floxed neo cassette. (J:218664)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf8 Mutation: 35 strains or lines available

References

• Original: J:218664 Wang H, et al., A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation. J Immunol. 2014 Aug 15;193(4):1766-77
• All: 14 reference(s)