Slc6a3^{tm2(HBEGF)Rpa}
Targeted Allele Detail

Summary

• Symbol: Slc6a3^{tm2(HBEGF)Rpa}
• Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 2, Richard D Palmiter
• MGI ID: MGI:5618169
• Synonyms: Slc6a3-DTR
• Gene: Slc6a3 Location: Chr13:73684866-73726791 bp, + strand Genetic Position: Chr13, 40.1 cM
• Alliance: Slc6a3^{tm2(HBEGF)Rpa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215916
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Slc6a3^{tm2(HBEGF)Rpa} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The human diphtheria toxin receptor open reading frame was inserted into the 5'-UTR region of exon 2, just upstream of the translation start codon of Slc6a3 to allow conditional killing of these cells upon diphtheria toxin treatment. (J:215916)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a3 Mutation: 66 strains or lines available

References

• Original: J:215916 Postupna NO, et al., Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease. Lab Invest. 2014 Oct;94(10):1161-72
• All: 3 reference(s)