Hepacam^tm1.2Tjj
Targeted Allele Detail

Summary

• Symbol: Hepacam^tm1.2Tjj
• Name: hepatocyte cell adhesion molecule; targeted mutation 1.2, Thomas J Jentsch
• MGI ID: MGI:5618262
• Gene: Hepacam Location: Chr9:37278652-37297868 bp, + strand Genetic Position: Chr9, 20.76 cM
• Alliance: Hepacam^tm1.2Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210308
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted into intron 1, a G98S mutation was introduced in exon 2, and an F3 flanked puro cassette and loxP site were inserted into intron 4 via homologous recombination. Flp mediated recombination removed the selection cassettes. Cre mediated recombination removed exons 2-4. (J:210308)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hepacam Mutation: 22 strains or lines available

References

• Original: J:210308 Hoegg-Beiler MB, et al., Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction. Nat Commun. 2014;5:3475
• All: 3 reference(s)