Syne2^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Syne2^tm1.1Chen
• Name: spectrin repeat containing, nuclear envelope 2; targeted mutation 1.1, Ju Chen
• MGI ID: MGI:5618421
• Synonyms: nesprin2^-
• Gene: Syne2 Location: Chr12:75865092-76157702 bp, + strand Genetic Position: Chr12, 33.11 cM
• Alliance: Syne2^tm1.1Chen page

Ultrastructural nuclear abnormalities in Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/? cardiomyocytes

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211007
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single exon was flanked by loxP sites with Frt-neo-Frt cassette before the second loxP sequence. Cre mediated recombination removed the single exon. (J:211007)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syne2 Mutation: 297 strains or lines available

References

• Original: J:211007 Banerjee I, et al., Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response. PLoS Genet. 2014 Feb;10(2):e1004114
• All: 1 reference(s)