Slc7a5^tm1.1Daca
Targeted Allele Detail

Summary

• Symbol: Slc7a5^tm1.1Daca
• Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; targeted mutation 1.1, Doreen A Cantrell
• MGI ID: MGI:5618433
• Synonyms: Slc7a5^fl, Slc7a5-Flox
• Gene: Slc7a5 Location: Chr8:122607885-122634425 bp, - strand Genetic Position: Chr8, Syntenic
• Alliance: Slc7a5^tm1.1Daca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196444
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains loxP sites flanking exon 1, including the initiation codon. An FRT-flanked neomycin resistance (neo) cassette fused to an internal ribosomal entry site (IRES) and a splice donor (SD) sequence, followed by a third loxP site, are placed downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo-IRES-SD cassette. (J:213820)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc7a5 Mutation: 34 strains or lines available

References

• Original: J:196444 Sinclair LV, et al., Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol. 2013 May;14(5):500-8
• All: 12 reference(s)