Hprt1^{tm1(CAG-Gys1*)Jjg}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CAG-Gys1*)Jjg}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Joan J Guinovart
• MGI ID: MGI:5618914
• Synonyms: mMGS-9A
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CAG-Gys1*)Jjg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218887
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(CAG-Gys1*)Jjg} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gys1 (MGI:101805)

• Mutation details: The CAG promoter, a floxed stop cassette and a mutated cDNA encoding a murine Gys1 gene with the 9 regulatory serines mutated to alanine were inserted into the locus via homologous recombination. (J:218887)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:218887 Duran J, et al., Deleterious effects of neuronal accumulation of glycogen in flies and mice. EMBO Mol Med. 2012 Aug;4(8):719-29
• All: 4 reference(s)