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Plcg2M2Btlr
Chemically induced Allele Detail
Summary
Symbol: Plcg2M2Btlr
Name: phospholipase C, gamma 2; mutation 2, Bruce Beutler
MGI ID: MGI:5619131
Synonyms: Poseidon
Gene: Plcg2  Location: Chr8:118225030-118361881 bp, + strand  Genetic Position: Chr8, 64.26 cM
Alliance: Plcg2M2Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a T to A transversion at base pair 117,615,238 (v38) on chromosome 8, or base pair 116,948 in the GenBank genomic region NC_000074 encoding Plcg2. The mutation corresponds to residue 3,532 in the mRNA sequence NM_172285 within exon 4 of 33 total exons. The mutation results in a tryptophan (W) to arginine (R) substitution at position 1113 (W1113R) in the phospholipase C gamma 2 (PLCgamma-2) protein. (J:218966)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plcg2 Mutation:  74 strains or lines available
References
Original:  J:218966 SoRelle J, et al., Mutagenetix entry for Poseidon. MGI Direct Data Submission. 2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory