Elane^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Elane^M1Btlr
• Name: elastase, neutrophil expressed; mutation 1, Bruce Beutler
• MGI ID: MGI:5619132
• Synonyms: Ruo
• Gene: Elane Location: Chr10:79722146-79724050 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Elane^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to G transition at base pair 79,887,108 (v38) on chromosome 10, or base pair 797 in the GenBank genomic region NC_000076. The mutation corresponds to residue 370 in the mRNA sequence NM_015779 within exon 4 of 5 total exons. The mutation results in an aspartic acid (D) to glycine (G) substitution at position 116 (D116G) in the neutrophil elastase protein. (J:218967)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elane Mutation: 23 strains or lines available

References

• Original: J:218967 Zhang Z, et al., Mutagenetix entry for Ruo. MGI Direct Data Submission. 2015
• All: 1 reference(s)