Rhot1^tm1.2Jmsu
Targeted Allele Detail

Summary

• Symbol: Rhot1^tm1.2Jmsu
• Name: ras homolog family member T1; targeted mutation 1.2, Janet M Shaw
• MGI ID: MGI:5619348
• Synonyms: Miro1 KO
• Gene: Rhot1 Location: Chr11:80099845-80158733 bp, + strand Genetic Position: Chr11, 47.62 cM, cytoband B5
• Alliance: Rhot1^tm1.2Jmsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216408
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The loxP flanked exon 2 was removed via cre-mediated recombination. (J:216408)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhot1 Mutation: 44 strains or lines available

References

• Original: J:216408 Nguyen TT, et al., Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3631-40
• All: 1 reference(s)