Rp2^tm1.2Asw
Targeted Allele Detail

Summary

• Symbol: Rp2^tm1.2Asw
• Name: retinitis pigmentosa 2 homolog; targeted mutation 1.2, Anand Swaroop
• MGI ID: MGI:5619358
• Gene: Rp2 Location: ChrX:20230778-20271873 bp, + strand Genetic Position: ChrX, 15.83 cM, cytoband A2
• Alliance: Rp2^tm1.2Asw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214194
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and cre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression in the eye. (J:214194)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rp2 Mutation: 6 strains or lines available

References

• Original: J:214194 Li L, et al., Ablation of the X-linked retinitis pigmentosa 2 (Rp2) gene in mice results in opsin mislocalization and photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2013 Jul;54(7):4503-11
• All: 4 reference(s)