Tg(Slc6a5-cre)1Uze
Transgene Detail

Summary

• Symbol: Tg(Slc6a5-cre)1Uze
• Name: transgene insertion 1, University of Zurich
• MGI ID: MGI:5619573
• Synonyms: GlyT2::Cre
• Transgene: Tg(Slc6a5-cre)1Uze Location: unknown
• Alliance: Tg(Slc6a5-cre)1Uze page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Slc6a5-cre)1Uze expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a5 (MGI:105090)

• Mutation details: The Cre coding sequence, with the bovine growth hormone polyadenylation signal, was inserted into the middle of exon 2 of the Sl6a5 gene in the BAC clone 365E4 from C57BL/6 BAC library RPCI-23. This BAC contains the entire coding sequence for both isoforms of the protein and 105 kb of 5' and 21 kb of 3' flanking genomic sequence. In transgenic mice, Cre expression is specific to neurons in the brain and spinal cord. (J:219115)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a5 (mouse) Summary of all recombinase alleles driven by Slc6a5. Comparative matrix view of recombinase activities Alliance mouse Slc6a5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:219115 Foster E, et al., Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch. Neuron. 2015 Mar 18;85(6):1289-1304
• All: 7 reference(s)