Vgf^{tm2(VGF*)Srjs}
Targeted Allele Detail

Summary

• Symbol: Vgf^{tm2(VGF*)Srjs}
• Name: VGF nerve growth factor inducible; targeted mutation 2, Stephen R J Salton
• MGI ID: MGI:5619978
• Gene: Vgf Location: Chr5:137055246-137062205 bp, + strand Genetic Position: Chr5, 76.13 cM
• Alliance: Vgf^{tm2(VGF*)Srjs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212045
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The mouse coding sequence was replaced by a BAC sequence containing a floxed human gene into which a single nucleotide substitution (rs3540074) was inserted to create a stop codon. The BAC sequence contained, in addition, an FRT flanked PGF-neo cassette. The inserted sequence encodes a truncated protein containing amino acids 1-524. (J:212045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vgf Mutation: 26 strains or lines available

References

• Original: J:212045 Fargali S, et al., The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J. 2014 May;28(5):2120-33
• All: 2 reference(s)