Myod1^{tm1.1(cre/ERT2)Lepr}
Targeted Allele Detail

Summary

• Symbol: Myod1^{tm1.1(cre/ERT2)Lepr}
• Name: myogenic differentiation 1; targeted mutation 1.1, Christoph Lepper
• MGI ID: MGI:5620011
• Synonyms: MyoD1^CE
• Gene: Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
• Alliance: Myod1^{tm1.1(cre/ERT2)Lepr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210509
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Myod1^{tm1.1(cre/ERT2)Lepr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myod1 (MGI:97275)

• Mutation details: A rabbit beta-globin intron, cre/ERT2 fusion gene, SV40 late polyadenylation signal and FRT-flanked neomycin cassette replaced the coding sequence in exon 1. Flp-mediated recombination removed the selection cassette. (J:210509)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myod1 (mouse) Summary of all recombinase alleles driven by Myod1. Comparative matrix view of recombinase activities Alliance mouse Myod1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myod1 Mutation: 23 strains or lines available

References

• Original: J:210509 Southard S, et al., A series of Cre-ER(T2) drivers for manipulation of the skeletal muscle lineage. Genesis. 2014 Aug;52(8):759-70
• All: 2 reference(s)