Snai3^tm1.2Jhws
Targeted Allele Detail

Summary

• Symbol: Snai3^tm1.2Jhws
• Name: snail family zinc finger 3; targeted mutation 1.2, John Weis
• MGI ID: MGI:5620192
• Synonyms: Snai3KO
• Gene: Snai3 Location: Chr8:123180947-123187472 bp, - strand Genetic Position: Chr8, 71.07 cM, cytoband E1
• Alliance: Snai3^tm1.2Jhws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204710
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site followed by a FRT-flanked neomycin resistance (neo) cassette upstream of exon 1, and a second loxP site downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 1 floxed. Cre-mediated recombination removed exon 1. Immunoblot analysis using testes demonstrates absence of protein. (J:204710)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snai3 Mutation: 17 strains or lines available

References

• Original: J:204710 Pioli PD, et al., Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency. PLoS One. 2013;8(7):e69216
• All: 2 reference(s)