Tg(CMV-GAA*P545L)#Kjv
Transgene Detail

Summary

• Symbol: Tg(CMV-GAA*P545L)#Kjv
• Name: transgene insertion, Kenneth J Valenzano
• MGI ID: MGI:5620661
• Synonyms: hP545L GAA Tg
• Transgene: Tg(CMV-GAA*P545L)#Kjv Location: unknown
• Alliance: Tg(CMV-GAA*P545L)#Kjv page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-GAA*P545L)#Kjv expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GAA (2548)

  Gaa	(MGI:95609)

• Mutation details: The human GAA gene with a P545L mutation is expressed under the control of a CMV promoter. This record represents data where the line number is not specified. (J:219022)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:219022 Khanna R, et al., The pharmacological chaperone AT2220 increases the specific activity and lysosomal delivery of mutant acid alpha-glucosidase, and promotes glycogen reduction in a transgenic mouse model of Pompe disease. PLoS One. 2014;9(7):e102092
• All: 1 reference(s)