Clec4a2^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Clec4a2^tm1Yiw
• Name: C-type lectin domain family 4, member a2; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:5620799
• Gene: Clec4a2 Location: Chr6:123099627-123119891 bp, + strand Genetic Position: Chr6, 58.18 cM, cytoband F3
• Alliance: Clec4a2^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217720
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1 and 2. Northern blot and RT-PCR analysis confirmed the absence of transcript expression. (J:217720)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec4a2 Mutation: 30 strains or lines available

References

• Original: J:217720 Fujikado N, et al., Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. Nat Med. 2008 Feb;14(2):176-80
• All: 8 reference(s)