Flnb^tm1Vshn
Targeted Allele Detail

Summary

• Symbol: Flnb^tm1Vshn
• Name: filamin, beta; targeted mutation 1, Volney Sheen
• MGI ID: MGI:5620800
• Synonyms: Flnb^-
• Gene: Flnb Location: Chr14:14518185-14651816 bp, - strand Genetic Position: Chr14, 4.59 cM
• Alliance: Flnb^tm1Vshn page

Premature differentiation within the prehypertrophic zone in the long bone growth plates of Flnb^tm1Vshn/Flnb^tm1Vshn mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125095
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3-5 were replaced by a neo selection cassette causing a frame shift mutation. Western blot analysis of P7 livers confirmed graded loss of protein expression in heterozygous and homozygous mutant mice. (J:125095)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Flnb Mutation: 153 strains or lines available

References

• Original: J:125095 Lu J, et al., Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet. 2007 Jul 15;16(14):1661-75
• All: 6 reference(s)